根据NetToPLCSim的说法：
NetToPLCSim don't cares about the rack/slot specifications, and handles a max. PDU size of 960 bytes.

Comments on testing NetToPLCSim with some SCADA/HMI-Systems:

Wonderware InTouch with DAServer
Works well.
Libnodave itself
Works well.
WinCC (V6.2 / V7)
Works. But you have to uncheck all options in system parameters at TCP/IP of the SIMATIC S7 Protocol Suite (Cycle management: by AS/ change driven transfer; Lifebeat monitoring; Monitoring of CPU-Stop)
WinCCflexible 2007/2008
Siemens WinCCflexible sometimes uses special protocol commands which NetToPLCSim doesn't support. But *** projects will mostly work. If you have large amounts of data and many cyclic data for alarming, WinCCflexible requests the PLC to send cyclic messages with this data without any request from flexible.
Simatic Net OPC Server
Works well. But you can't browse the PLC with the OPC-Scout, because it asks the PLC which data blocks are present in the PLC. Nevertheless you can read/write this data.

It will work with any other driver that uses S7-Communication (no configuration or programming in the PLC is needed), and uses no special functions